Date & Time of Session - 11/6/25 - from 12-1PM

Overview
Combination antimicrobial therapy for gram positive bacteremia has been previously touched upon by national presentations. The UofL Health antimicrobial stewardship program educates providers and fellow pharmacists on proper usage of antimicrobials and helps triage usage of clinical use criteria antimicrobial therapy. The indication for usage of multiple antimicrobials in gram negative bacteremia has not been well discussed within the health system. Providers, nursing staff, and pharmacists will be exposed to the latest literature on this topic which currently does not have updated guidelines. The aim of this presentation is to improve the usage of antimicrobials by providers and as a result patient outcomes in patients with gram negative bacteremia.

This lecture will provide a comprehensive overview of treatment of several gram negative pathogens with respect for the indication of mono vs dual antimicrobial therapy. The audience will be introduced to different pathogens and why mono or dual therapy is indicated or preferred in respective clinical scenarios.

Objectives
Upon completion of this activity, the participant will be able to:
1. Assess scenarios in which monotherapy is suitable for treatment in gram-negative bacteremia
2. Determine clinical situations where escalating to dual antimicrobial therapy would be appropriate
3. Categorize gram-negative pathogens where monotherapy vs combination therapy would be preferred empirically

Speakers
Keaton Prebble, PharmD
PGY2 Infectious Diseases Pharmacy Resident
UofL Health – Louisville, Kentucky